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OSBP2 Antikörper (AA 221-320) (Cy3)

OSBP2 Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN718079
  • Target Alle OSBP2 Antikörper anzeigen
    OSBP2 (Oxysterol Binding Protein 2 (OSBP2))
    Bindungsspezifität
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 221-320
    Reaktivität
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 18
    • 1
    • 1
    Kaninchen
    Klonalität
    • 19
    • 1
    Polyklonal
    Konjugat
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser OSBP2 Antikörper ist konjugiert mit Cy3
    Applikation
    • 19
    • 12
    • 12
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human OSBP2
    Isotyp
    IgG
    Top Product
    Discover our top product OSBP2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    OSBP2 (Oxysterol Binding Protein 2 (OSBP2))
    Andere Bezeichnung
    OSBP2 (OSBP2 Produkte)
    Synonyme
    ORP-4 antikoerper, ORP4 antikoerper, OSBPL1 antikoerper, OSBPL4 antikoerper, 1700095P05Rik antikoerper, C630001G20Rik antikoerper, Gm244 antikoerper, RGD1309479 antikoerper, oxysterol binding protein 2 antikoerper, OSBP2 antikoerper, Osbp2 antikoerper
    Hintergrund

    Synonyms: ORP 4, ORP4, OSBLP4, OSBP-related protein 4, OSBP2, OSBPL1, OSBPL4, Oxysterol Binding Protein 2, Oxysterol Binding Protein-like 1, oxysterol binding protein-related protein 4, OSBP2_HUMAN.

    Background: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.

    Gen-ID
    23762
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