AKAP8L Antikörper (AA 596-646)

Produktnummer ABIN7448929

Produktdetails anti-AKAP8L Antikörper

Target: AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))

Bindungsspezifität: AA 596-646

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKAP8L Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Verwendungszweck: Rabbit anti-AKAP8L/HA95 IHC Antibody, Affinity Purified

Homologie: Gorilla,Chimpanzee,Chinese hamster,Northern white-cheeked gibbon,Naked mole rat

Aufreinigung: Affinity Purified

Immunogen: Between AA 596 and 646

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu AKAP8L

Target: AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))

Andere Bezeichnung: AKAP8L/HA95 (AKAP8L Produkte)

Synonyme: HA95 antikoerper, HAP95 antikoerper, NAKAP antikoerper, NAKAP95 antikoerper, Nakap95 antikoerper, zgc:85966 antikoerper, AKAP8L antikoerper, A-kinase anchoring protein 8 like antikoerper, A kinase (PRKA) anchor protein 8-like antikoerper, A-kinase anchoring protein 8 like L homeolog antikoerper, AKAP8L antikoerper, Akap8l antikoerper, akap8l antikoerper, akap8l.L antikoerper

Hintergrund: Background: AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington's disease.

Gen-ID: 26993

NCBI Accession: NP_055186

UniProt: Q9ULX6

Pathways: SARS-CoV-2 Protein Interaktom