p40 (p63 Delta) (AA 1-50) Antikörper
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- Target
- p40 (p63 Delta)
- Bindungsspezifität
- AA 1-50
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Verwendungszweck
- Mouse anti-p40 Monoclonal Antibody [BC28]
- Immunogen
- between AA 1 and 50
- Klon
- BC28
- Isotyp
- IgG
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- Applikationshinweise
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IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
WB: 17:40:00
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 250 μg/mL
- Buffer
- Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Haltbarkeit
- 12 months
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- Target
- p40 (p63 Delta)
- Andere Bezeichnung
- p40
- Synonyme
- AIS antikoerper, B(p51A) antikoerper, B(p51B) antikoerper, EEC3 antikoerper, KET antikoerper, LMS antikoerper, NBP antikoerper, OFC8 antikoerper, RHS antikoerper, SHFM4 antikoerper, TP53CP antikoerper, TP53L antikoerper, TP73L antikoerper, p40 antikoerper, p51 antikoerper, p53CP antikoerper, p63 antikoerper, p73H antikoerper, p73L antikoerper, tumor protein p63 antikoerper, TP63 antikoerper
- Hintergrund
- Background: Tumor protein p63 is a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. P63 is an extremely sensitive marker of lung squamous cell carcinoma, but it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types. P40 is a splice isoform of p63 known as DeltaNp63 and has been demonstrated to be highly specific for squamous/basal cells making it is markedly superior to p63 in specificity [adapted from NCBI Entrez Gene (Gene ID: 8626)].
- Gen-ID
- 8626
- NCBI Accession
- NP_003713
- UniProt
- Q9H3D4
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