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MHC Class II HLA-DP/DQ/DR Antikörper

HLA-DP/DQ/DR Reaktivität: Human WB, IHC, ICC Wirt: Maus Monoclonal CR3-43 unconjugated
Produktnummer ABIN7449429
  • Target Alle MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR) Produkte
    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
    Reaktivität
    • 21
    • 1
    Human
    Wirt
    • 19
    • 2
    Maus
    Klonalität
    • 21
    Monoklonal
    Konjugat
    • 11
    • 4
    • 2
    • 2
    • 1
    • 1
    Dieser MHC Class II HLA-DP/DQ/DR Antikörper ist unkonjugiert
    Applikation
    • 20
    • 8
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Verwendungszweck
    Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]
    Immunogen
    Cells from human tonsil
    Klon
    CR3-43
    Isotyp
    IgG
  • Applikationshinweise

    IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

    WB: 01:01,00

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    250 μg/mL
    Buffer
    Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Haltbarkeit
    12 months
  • Target
    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
    Andere Bezeichnung
    HLA-DR/DP/DQ (HLA-DP/DQ/DR Produkte)
    Hintergrund
    Background: In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ~70 % similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.
    Gen-ID
    3122
    NCBI Accession
    NP_061984
    UniProt
    P01903
    Pathways
    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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