Claspin Antikörper (AA 900-950)

Produktnummer ABIN7449673

Produktdetails anti-Claspin Antikörper

Target: Claspin (CLSPN)

Bindungsspezifität: AA 900-950

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claspin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-Claspin Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 900 and 950

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Claspin

Target: Claspin (CLSPN)

Andere Bezeichnung: Claspin (CLSPN Produkte)

Synonyme: CLSPN antikoerper, xClaspin antikoerper, B130025E01 antikoerper, C85083 antikoerper, E130314M08Rik antikoerper, claspin antikoerper, claspin S homeolog antikoerper, Clspn antikoerper, CLSPN antikoerper, clspn antikoerper, clspn.S antikoerper

Hintergrund: Background: Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.

Gen-ID: 63967

UniProt: Q9HAW4