SPEN Antikörper (AA 1350-1400)

Produktnummer ABIN7451040

Produktdetails anti-SPEN Antikörper

Target: SPEN (Spen Homolog, Transcriptional Regulator (SPEN))

Bindungsspezifität: AA 1350-1400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPEN Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-SHARP Antibody, Affinity Purified

Homologie: Mouse

Aufreinigung: Affinity Purified

Immunogen: between AA 1350 and 1400

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: Not recommended for crude preparations. ABIN7451040 can be used successfully for WB of enriched preparations (e.g. immunoprecipitated) SHARP.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu SPEN

Target: SPEN (Spen Homolog, Transcriptional Regulator (SPEN))

Andere Bezeichnung: SHARP (SPEN Produkte)

Hintergrund: Background: SHARP functions as a transcriptional repressor by interacting with proteins involved in deacetylation such as the NuRD (nucleosome remodeling) complex. SHARP can also repress transcription by interacting with corepressors such as SMRT/NCoR (silencing mediator for retinoid and thyroid receptors/nuclear receptor corepressor). SHARP is able to suppress transcription through the Notch/RBP-J signaling pathway by competing RBP-J binding with the intracellular domain of Notch.

Gen-ID: 23013

NCBI Accession: NP_055816

UniProt: Q96T58