Nischarin Antikörper (AA 1100-1150)
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- Target Alle Nischarin (NISCH) Antikörper anzeigen
- Nischarin (NISCH)
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Bindungsspezifität
- AA 1100-1150
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Nischarin Antikörper ist unkonjugiert
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Applikation
- Immunoprecipitation (IP)
- Verwendungszweck
- Rabbit anti-NISCH Antibody, Affinity Purified
- Aufreinigung
- Affinity Purified
- Immunogen
- Between AA 1100 and 1150
- Isotyp
- IgG
- Top Product
- Discover our top product NISCH Primärantikörper
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- Applikationshinweise
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IP: 2 - 10 μg/mg lysate
WB: Not recommended. ABIN7451170 has not performed satisfactorily when used for WB of NISCH in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of NISCH.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Haltbarkeit
- 12 months
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- Target
- Nischarin (NISCH)
- Andere Bezeichnung
- NISCH (NISCH Produkte)
- Synonyme
- NISCH antikoerper, IRAS antikoerper, 1200007D05Rik antikoerper, 3202002H23Rik antikoerper, AW494485 antikoerper, I-1 antikoerper, IR1 antikoerper, hIRAS antikoerper, nischarin antikoerper, nischarin S homeolog antikoerper, NISCH antikoerper, Cyan7822_6841 antikoerper, nisch.S antikoerper, nisch antikoerper, Nisch antikoerper
- Hintergrund
- Background: Nischarin (NISCH) is a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of NISCH was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation[taken from NCBI Entrez Gene (Gene ID: 11188)].
- Gen-ID
- 11188
- UniProt
- Q9Y2I1
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