PITRM1 Antikörper (AA 987-1037)

Produktnummer ABIN7451174

Produktdetails anti-PITRM1 Antikörper

Target: PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))

Bindungsspezifität: AA 987-1037

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PITRM1 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-PITRM1 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 987 and 1037

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. ABIN7451174 has not performed satisfactorily when used for WB of PITRM1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of PITRM1.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PITRM1

Target: PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))

Andere Bezeichnung: PITRM1 (PITRM1 Produkte)

Synonyme: MP1 antikoerper, PreP antikoerper, 2310012C15Rik antikoerper, AA410010 antikoerper, MP-1 antikoerper, Ntup1 antikoerper, mKIAA1104 antikoerper, PITRM1 antikoerper, wu:fa03d09 antikoerper, zgc:55469 antikoerper, pitrilysin metallopeptidase 1 antikoerper, pitrilysin metallepetidase 1 antikoerper, pitrilysin metallopeptidase 1 L homeolog antikoerper, PITRM1 antikoerper, Pitrm1 antikoerper, pitrm1.L antikoerper, pitrm1 antikoerper

Hintergrund: Background: Pitrilysin metalloproteinase 1 (PITRM1) is an ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. PITRM1 also degrades other unstructured peptides. It is specific for peptides in the range of 10 to 65 residues. It is able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. PTMRM shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference [taken from the Universal Protein Resource (UniProt) Q5JRX3].

Gen-ID: 10531

UniProt: Q5JRX3

Pathways: PI3K-Akt Signalweg, SARS-CoV-2 Protein Interaktom