IMPA1 Antikörper (AA 25-75)

Produktnummer ABIN7451266

Produktdetails anti-IMPA1 Antikörper

Target: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Bindungsspezifität: AA 25-75

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IMPA1 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-IMPA1 Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: Between AA 25 and 75

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-IMPA1 antibody ABIN7450359.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu IMPA1

Target: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Andere Bezeichnung: IMPA1 (IMPA1 Produkte)

Synonyme: zgc:100926 antikoerper, 2610002K09Rik antikoerper, 2900059K10Rik antikoerper, AI325909 antikoerper, IMP antikoerper, IMPA antikoerper, impa antikoerper, inositol monophosphatase 1 antikoerper, inositol(myo)-1(or 4)-monophosphatase 1 antikoerper, inositol (myo)-1(or 4)-monophosphatase 1 antikoerper, inositol monophosphatase antikoerper, inositol(myo)-1(or 4)-monophosphatase 1 S homeolog antikoerper, impa1 antikoerper, Impa1 antikoerper, IMPA1 antikoerper, impa1.S antikoerper

Hintergrund: Background: Inositol monophosphatase 1 (IMPA1) is an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorde [taken from NCBI Entrez Gene (Gene ID: 3612)].

Gen-ID: 3612

UniProt: P29218