RRP8 Antikörper (AA 406-456)

Produktnummer ABIN7451332

Produktdetails anti-RRP8 Antikörper

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Bindungsspezifität: AA 406-456

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRP8 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-RRP8 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 406 and 456

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-RRP8 antibody ABIN7453202.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu RRP8

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Andere Bezeichnung: RRP8 (RRP8 Produkte)

Synonyme: KIAA0409 antikoerper, 1500003O22Rik antikoerper, 2900001K19Rik antikoerper, AW538116 antikoerper, RGD1308302 antikoerper, ribosomal RNA processing 8 antikoerper, ribosomal RNA processing 8, methyltransferase, homolog (yeast) antikoerper, RRP8 antikoerper, Rrp8 antikoerper

Hintergrund: Background: Ribosomal RNA-processing protein (RRP8) is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown [taken from the Universal Protein Resource (UniProt) O43159].

Gen-ID: 23378

NCBI Accession: NP_056139

UniProt: O43159