TOPBP1 Antikörper (C-Term)

Produktnummer ABIN7452107

Produktdetails anti-TOPBP1 Antikörper

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOPBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-TopBP1 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 1400 and C-term

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TOPBP1

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Andere Bezeichnung: TopBP1 (TOPBP1 Produkte)

Synonyme: RGD1562949 antikoerper, TOPBP1 antikoerper, cut5 antikoerper, F2P24.3 antikoerper, F2P24_3 antikoerper, meiosis defective 1 antikoerper, TOP2BP1 antikoerper, 1110031N14Rik antikoerper, 2810429C13Rik antikoerper, AI256758 antikoerper, D430026L04Rik antikoerper, mKIAA0259 antikoerper, TopBP1-A antikoerper, TopBP1-B antikoerper, Xmus101 antikoerper, XtopBP antikoerper, mus101 antikoerper, top2bp1 antikoerper, DNA topoisomerase II binding protein 1 antikoerper, topoisomerase (DNA) II binding protein 1 antikoerper, dna topoisomerase ii binding protein 1 (IC) antikoerper, transcription coactivator antikoerper, DNA topoisomerase II binding protein 1 L homeolog antikoerper, Topbp1 antikoerper, topbp1 antikoerper, TOPBP1 antikoerper, MEI1 antikoerper, topbp1.L antikoerper

Hintergrund: Background: Topoisomerases regulate topological states of DNA. DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.

Gen-ID: 11073

NCBI Accession: NP_008958

UniProt: Q92547

Pathways: Chromatin Binding