Mahogunin RING Finger Protein 1 Antikörper (AA 505-555)

Produktnummer ABIN7452524

Produktdetails anti-Mahogunin RING Finger Protein 1 Antikörper

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Bindungsspezifität: AA 505-555

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Mahogunin RING Finger Protein 1 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-MGRN1 Antibody, Affinity Purified

Homologie: Gorilla,Chimpanzee

Aufreinigung: Affinity Purified

Immunogen: between AA 505 and 555

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: Not recommended

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Mahogunin RING Finger Protein 1

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Andere Bezeichnung: MGRN1 (MGRN1 Produkte)

Synonyme: RNF156 antikoerper, 2610042J20Rik antikoerper, mKIAA0544 antikoerper, md antikoerper, nc antikoerper, RGD1311862 antikoerper, mgrn1 antikoerper, wu:fi38c03 antikoerper, zgc:55978 antikoerper, mahogunin ring finger 1 antikoerper, mahogunin, ring finger 1 antikoerper, mahogunin ring finger 1, E3 ubiquitin protein ligase S homeolog antikoerper, mahogunin ring finger 1, E3 ubiquitin protein ligase antikoerper, mahogunin, ring finger 1a antikoerper, MGRN1 antikoerper, Mgrn1 antikoerper, mgrn1.S antikoerper, mgrn1 antikoerper, mgrn1a antikoerper

Hintergrund: Background: MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) O60291].

Gen-ID: 23295

NCBI Accession: NP_001135761

UniProt: O60291

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling