KIAA1524 Antikörper (N-Term)

Produktnummer ABIN7452647

Produktdetails anti-KIAA1524 Antikörper

Target: KIAA1524

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KIAA1524 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Mouse anti-CIP2A Monoclonal Antibody, Affinity Purified [2A1-9A4]

Aufreinigung: Affinity Purified

Immunogen: Amino terminal one-third of the CIP2A (GeneID 57650) recombinant protein

Klon: 2A1-9A4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20 μL/mg lysate

WB: 17:40:00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 40 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu KIAA1524

Target: KIAA1524

Andere Bezeichnung: CIP2A (KIAA1524 Produkte)

Hintergrund: Background: CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.

Gen-ID: 57650

NCBI Accession: NP_065941

UniProt: Q8TCG1