FAM105B Antikörper (AA 75-125)

Produktnummer ABIN7452665

Produktdetails anti-FAM105B Antikörper

Target: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Bindungsspezifität: AA 75-125

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM105B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-OTULIN Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 75 and 125

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20-40 μL/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu FAM105B

Target: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Andere Bezeichnung: OTULIN (FAM105B Produkte)

Synonyme: C79097 antikoerper, OTU deubiquitinase with linear linkage specificity antikoerper, OTULIN antikoerper, Otulin antikoerper

Hintergrund: Background: Otulin is a deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. [taken from the Universal Protein Resource (UniProt) Q96BN8].

Gen-ID: 90268

UniProt: Q96BN8