CNOT1 Antikörper (AA 1400-1450)

Produktnummer ABIN7452794

Produktdetails anti-CNOT1 Antikörper

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Bindungsspezifität: AA 1400-1450

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNOT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-CNOT1 Antibody, Affinity Purified

Homologie: Zebrafish,X. tropicalis

Aufreinigung: Affinity Purified

Immunogen: between AA 1400 and 1450

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 50 - 100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu CNOT1

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Andere Bezeichnung: CNOT1 (CNOT1 Produkte)

Hintergrund: Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. [taken from NCBI Entrez Gene (Gene ID: 23019)]. [taken from the Universal Protein Resource (UniProt) A5YKK6].

Gen-ID: 23019

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance