TBC1D23 Antikörper (AA 525-575)
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- Target Alle TBC1D23 Produkte
- TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
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Bindungsspezifität
- AA 525-575
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TBC1D23 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP)
- Verwendungszweck
- Rabbit anti-TBC1D23 Antibody, Affinity Purified
- Homologie
- Mouse,Zebrafish,X. laevis,Chicken,Orangutan
- Aufreinigung
- Affinity Purified
- Immunogen
- between AA 525 and 575
- Isotyp
- IgG
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- Applikationshinweise
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IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Haltbarkeit
- 12 months
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- Target
- TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
- Andere Bezeichnung
- TBC1D23 (TBC1D23 Produkte)
- Synonyme
- RGD1307925 antikoerper, NS4ATP1 antikoerper, 4930451A13Rik antikoerper, AU015720 antikoerper, AU043671 antikoerper, AU043778 antikoerper, D030022P07Rik antikoerper, W51689 antikoerper, zgc:63756 antikoerper, TBC1 domain family, member 23 antikoerper, TBC1 domain family member 23 antikoerper, Tbc1d23 antikoerper, TBC1D23 antikoerper, tbc1d23 antikoerper
- Hintergrund
- Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].
- Gen-ID
- 55773
- UniProt
- Q9NUY8
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