TBC1D23 Antikörper (AA 525-575)

Produktnummer ABIN7452842

Produktdetails anti-TBC1D23 Antikörper

Target: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Bindungsspezifität: AA 525-575

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBC1D23 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-TBC1D23 Antibody, Affinity Purified

Homologie: Mouse,Zebrafish,X. laevis,Chicken,Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 525 and 575

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TBC1D23

Target: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Andere Bezeichnung: TBC1D23 (TBC1D23 Produkte)

Hintergrund: Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].

Gen-ID: 55773

UniProt: Q9NUY8