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TBC1D23 Antikörper (AA 525-575)

TBC1D23 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7452842
  • Target Alle TBC1D23 Produkte
    TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
    Bindungsspezifität
    • 4
    • 1
    • 1
    • 1
    AA 525-575
    Reaktivität
    • 9
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 9
    Kaninchen
    Klonalität
    • 9
    Polyklonal
    Konjugat
    • 6
    • 1
    • 1
    • 1
    Dieser TBC1D23 Antikörper ist unkonjugiert
    Applikation
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Verwendungszweck
    Rabbit anti-TBC1D23 Antibody, Affinity Purified
    Homologie
    Mouse,Zebrafish,X. laevis,Chicken,Orangutan
    Aufreinigung
    Affinity Purified
    Immunogen
    between AA 525 and 575
    Isotyp
    IgG
  • Applikationshinweise

    IP: 50-100 μL/mg lysate

    WB: 1:10,000 - 1:25,000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1000 μg/mL
    Buffer
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Haltbarkeit
    12 months
  • Target
    TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
    Andere Bezeichnung
    TBC1D23 (TBC1D23 Produkte)
    Synonyme
    RGD1307925 antikoerper, NS4ATP1 antikoerper, 4930451A13Rik antikoerper, AU015720 antikoerper, AU043671 antikoerper, AU043778 antikoerper, D030022P07Rik antikoerper, W51689 antikoerper, zgc:63756 antikoerper, TBC1 domain family, member 23 antikoerper, TBC1 domain family member 23 antikoerper, Tbc1d23 antikoerper, TBC1D23 antikoerper, tbc1d23 antikoerper
    Hintergrund
    Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].
    Gen-ID
    55773
    UniProt
    Q9NUY8
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