PCNT Antikörper (AA 175-225)

Produktnummer ABIN7453380

Produktdetails anti-PCNT Antikörper

Target: PCNT (Pericentrin (PCNT))

Bindungsspezifität: AA 175-225

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCNT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC)

Verwendungszweck: Rabbit anti-Pericentrin/Kendrin Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 175 and 225

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ICC-IF: 1:1,000 - 1:5,000. Formaldehyde or Acetone fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PCNT

Target: PCNT (Pericentrin (PCNT))

Andere Bezeichnung: Pericentrin/Kendrin (PCNT Produkte)

Hintergrund: Background: Pericentrin (PCNT) is a large centrosomal protein that binds calmodulin and mediates assembly of the mitotic spindle apparatus. Depletion of PCNT has been shown to cause apoptosis and activation of the G2/M checkpoint. Recently, mutations in the pericentrin gene have been identified as the cause of primordial dwarfism type II (MOPDII) and Seckel syndrome. Additionally, in cells of Seckel syndrome patients, PCNT has been found to be important to the DNA damage response and ATR-dependent checkpoint signaling.

Gen-ID: 5116

NCBI Accession: NP_006022

UniProt: O95613

Pathways: Sensory Perception of Sound, M Phase, SARS-CoV-2 Protein Interaktom