RRAGA Antikörper (AA 544-594)

Produktnummer ABIN7453480

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RRAGA in WB, IP und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RRAGA Antikörper (AA 544-594) (ABIN7453480)

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRAGA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-RRAGA Antikörper

Bindungsspezifität: AA 544-594

Verwendungszweck: Rabbit anti-FIP1 Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 544 and 594

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu RRAGA

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Andere Bezeichnung: FIP1

Hintergrund: Background: FIP1 was originally identified as Rhe (rearranged in hypereosinophilia) and part of a fusion protein encoded by a genetic rearrangement between the N-terminal region of FIP1 (Rhe) and the C-terminal region of the platelet-derived growth factor receptor alpha (PDGFRalpha). The fusion protein exhibits aberrant tyrosine kinase activity and is associated with hypereosinophilic syndrome (HES), a rare hematologic disorder characterized by an overproduction of eosinophils that results in organ damage. FIP1 was also identified as FIP1-like 1 in a database search for a human homolog of the yeast Fip1p (factor interacting with PAP), a subunit of the yeast 3'-end processing complex, CPF (cleavage and polyadenylation factor). Human FIP1 was similarly found to interact with PAP and CPSF160 as part of the human CPSF (cleavage and polyadenylation specificity factor) complex. In association with CPSF160, FIP1 is able to recognize U-rich elements on pre-mRNA and stimulate PAP activity.

Gen-ID: 81608

NCBI Accession: NP_112179

UniProt: Q6UN15