Rekombinanter UBQLN4 Antikörper (AA 2-601)

Produktnummer ABIN7453990

Produktdetails anti-UBQLN4 Antikörper

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: AA 2-601

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser UBQLN4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Verwendungszweck: Rabbit anti-UBQLN4/CIP75/Ubiquilin 4 Recombinant Monoclonal Antibody [BLR145J]

Immunogen: residues 2-601 (full length)

Klon: BLR145J

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Andere Bezeichnung: UBQLN4/CIP75/Ubiquilin 4 (UBQLN4 Produkte)

Synonyme: a1u antikoerper, cip75 antikoerper, ubin antikoerper, ubiquilin-4 antikoerper, A1U antikoerper, A1Up antikoerper, C1orf6 antikoerper, CIP75 antikoerper, UBIN antikoerper, A1u antikoerper, AI663987 antikoerper, RGD1308273 antikoerper, ubiquilin 4 L homeolog antikoerper, ubiquilin 4 antikoerper, ubqln4.L antikoerper, ubqln4 antikoerper, UBQLN4 antikoerper, Ubqln4 antikoerper

Hintergrund: Background: Ubiquilin-4 (UBQLN4) plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). It mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. UBQLN4 Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). It acts as an adapter protein that recruits UBQLN1 to the autophagy machinery and mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) [taken from NCBI Entrez Gene (Gene ID: 56893)].

Gen-ID: 56893

NCBI Accession: NP_064516

UniProt: Q9NRR5