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MAML2 Antikörper (C-Term)

MAML2 Reaktivität: Human, Maus WB, IP, IHC (fp) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7454661
  • Target Alle MAML2 Antikörper anzeigen
    MAML2 (Mastermind-Like 2 (MAML2))
    Bindungsspezifität
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 26
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Maus
    Wirt
    • 16
    • 11
    Kaninchen
    Klonalität
    • 16
    • 11
    Polyklonal
    Konjugat
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAML2 Antikörper ist unkonjugiert
    Applikation
    • 22
    • 12
    • 11
    • 9
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
    Verwendungszweck
    Rabbit anti-MAML2 Antibody, Affinity Purified
    Homologie
    Bovine
    Aufreinigung
    Affinity Purified
    Immunogen
    between AA 1100 and C-term
    Isotyp
    IgG
    Top Product
    Discover our top product MAML2 Primärantikörper
  • Applikationshinweise

    IHC: 1:200 - 1:1,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

    IP: 1 - 4 μg/mg lysate

    WB: 1:2,000 - 1:15,000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Haltbarkeit
    12 months
  • Target
    MAML2 (Mastermind-Like 2 (MAML2))
    Andere Bezeichnung
    MAML2 (MAML2 Produkte)
    Synonyme
    5930431H10 antikoerper, BC032967 antikoerper, MAM-3 antikoerper, MAM2 antikoerper, MAM3 antikoerper, MLL-MAML2 antikoerper, mastermind like 2 (Drosophila) antikoerper, mastermind-like transcriptional coactivator 2 antikoerper, mastermind like transcriptional coactivator 2 antikoerper, Maml2 antikoerper, MAML2 antikoerper
    Hintergrund
    Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
    Gen-ID
    84441
    UniProt
    Q8IZL2
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