PALB2 Antikörper (AA 675-725)

Produktnummer ABIN7454733

Produktdetails anti-PALB2 Antikörper

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Bindungsspezifität: AA 675-725

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PALB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Verwendungszweck: Rabbit anti-PALB2 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 675 and 725

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PALB2

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Andere Bezeichnung: PALB2 (PALB2 Produkte)

Synonyme: PALB2 antikoerper, Fancn antikoerper, si:ch211-14k19.9 antikoerper, FANCN antikoerper, PNCA3 antikoerper, 4732427B05 antikoerper, BC066140 antikoerper, RGD1304759 antikoerper, partner and localizer of BRCA2 antikoerper, partner and localizer of BRCA2 L homeolog antikoerper, PALB2 antikoerper, palb2 antikoerper, palb2.L antikoerper, Palb2 antikoerper

Hintergrund: Background: PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.

Gen-ID: 79728

NCBI Accession: NP_078951

UniProt: Q86YC2

Pathways: DNA Reparatur