SENP3 Antikörper (AA 275-325)

Produktnummer ABIN7454900

Produktdetails anti-SENP3 Antikörper

Target: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Bindungsspezifität: AA 275-325

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Verwendungszweck: Rabbit anti-SENP3 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 275 and 325

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu SENP3

Target: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Andere Bezeichnung: SENP3 (SENP3 Produkte)

Synonyme: SMT3IP1 antikoerper, SSP3 antikoerper, Ulp1 antikoerper, AA408656 antikoerper, Smt3ip antikoerper, Smt3ip1 antikoerper, ssp3 antikoerper, smt3ip1 antikoerper, fa03d07 antikoerper, wu:fa03d07 antikoerper, senp3 antikoerper, SUMO1/sentrin/SMT3 specific peptidase 3 antikoerper, SUMO/sentrin specific peptidase 3 antikoerper, Sumo1/sentrin/SMT3 specific peptidase 3 antikoerper, SUMO1/sentrin/SMT3 specific peptidase 3b antikoerper, SUMO1/sentrin/SMT3 specific peptidase 3 L homeolog antikoerper, SENP3 antikoerper, Senp3 antikoerper, senp3 antikoerper, senp3b antikoerper, senp3.L antikoerper

Hintergrund: Background: Sentrin-specific protease 3 (SENP3) functions as a protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates.SENP3 deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability, and also deconjugates SUMO2 and SUMO3 from CDCA8. SENP3 can function as a redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. SENP3 is required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 [taken from the Universal Protein Resource (UniProt) Q9H4L4].

Gen-ID: 26168

NCBI Accession: NP_056485

UniProt: Q9H4L4