TDG Antikörper (N-Term)

Produktnummer ABIN7464910

Produktdetails anti-TDG Antikörper

Target: TDG (Thymine-DNA Glycosylase (TDG))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TDG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified by antigen-affinity chromatography.

Güteklasse: KO Validated

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human TDG. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:5000-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: rat brain , HeLa , TDG-transfected 293T

Validation: KO/KD, Overexpression

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu TDG

Target: TDG (Thymine-DNA Glycosylase (TDG))

Andere Bezeichnung: thymine DNA glycosylase (TDG Produkte)

Synonyme: 5-MCDG antikoerper, wu:fb44b11 antikoerper, zgc:110622 antikoerper, MGC82456 antikoerper, MGC89441 antikoerper, E130317C12Rik antikoerper, JZA-3 antikoerper, Jza1 antikoerper, hTDG antikoerper, thymine DNA glycosylase antikoerper, thymine DNA glycosylase, tandem duplicate 1 antikoerper, putative g/t mismatch-specific thymine DNA glycosylase antikoerper, G/T mismatch-specific thymine DNA glycosylase antikoerper, thymine DNA glycosylase S homeolog antikoerper, thymine-DNA glycosylase antikoerper, TDG antikoerper, tdg.1 antikoerper, Smp_149220 antikoerper, Tsp_05734 antikoerper, tdg.S antikoerper, tdg antikoerper, Tdg antikoerper

Hintergrund: Thymine DNA glycosylase , hTDG,The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]

Molekulargewicht: 46 kDa

Gen-ID: 6996

UniProt: Q13569

Pathways: DNA Reparatur, Chromatin Binding