THO Complex 5 Antikörper

Produktnummer ABIN7465105

Produktdetails anti-THO Complex 5 Antikörper

Target: THO Complex 5 (THOC5)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THO Complex 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human THOC5. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: 293T , A431 , HeLa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu THO Complex 5

Target: THO Complex 5 (THOC5)

Andere Bezeichnung: THO complex 5 (THOC5 Produkte)

Synonyme: C22orf19 antikoerper, Fmip antikoerper, PK1.3 antikoerper, fSAP79 antikoerper, 1700060C24Rik antikoerper, A430085L24Rik antikoerper, Sgk2 antikoerper, fc54b09 antikoerper, wu:fc54b09 antikoerper, zgc:56190 antikoerper, zgc:76912 antikoerper, THOC5 antikoerper, fmip antikoerper, thoc5 antikoerper, thoc5-a antikoerper, thoc5-b antikoerper, THO complex 5 antikoerper, THO complex 5 S homeolog antikoerper, THO complex 5 L homeolog antikoerper, THOC5 antikoerper, Thoc5 antikoerper, thoc5 antikoerper, thoc5.S antikoerper, thoc5.L antikoerper

Hintergrund: THO complex 5 , C22orf19 , Fmip , PK1.3 , fSAP79,Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.

Molekulargewicht: 79 kDa

Gen-ID: 8563

UniProt: Q13769