HLA-DQB1 Antikörper
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- Target Alle HLA-DQB1 Antikörper anzeigen
- HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HLA-DQB1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Human
- Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human HLA-DQB1. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product HLA-DQB1 Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Positive Control: Jurkat
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.7 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))
- Andere Bezeichnung
- major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1 Produkte)
- Synonyme
- CELIAC1 antikoerper, HLA-DQB antikoerper, IDDM1 antikoerper, mhc-DRB antikoerper, DLA-DQB antikoerper, MAMU-DQB1 antikoerper, LOC100172120 antikoerper, DKFZp469C0237 antikoerper, major histocompatibility complex, class II, DQ beta 1 antikoerper, HLA-DQB1 antikoerper, PATR-DQB1 antikoerper, DLA-DQB1 antikoerper, MAMU-DQB1 antikoerper, LOC100172120 antikoerper
- Hintergrund
- Major histocompatibility complex, class II, DQ beta 1 , CELIAC1 , HLA-DQB , IDDM1,HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
- Molekulargewicht
- 30 kDa
- Gen-ID
- 3119
- UniProt
- P01920
- Pathways
- T-Zell Rezeptor Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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