PMS2CL/PMS2 Antikörper (N-Term)

Produktnummer ABIN7468755

Produktdetails anti-PMS2CL/PMS2 Antikörper

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMS2CL/PMS2 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human PMS2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:10000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: human PMS2-transfected 293T cells , A431 , HeLa , HepG2 Validation: Overexpression

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu PMS2CL/PMS2

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Andere Bezeichnung: PMS1 homolog 2, mismatch repair system component (PMS2 Produkte)

Synonyme: HNPCC4 antikoerper, PMS2CL antikoerper, PMSL2 antikoerper, PMS1 homolog 2, mismatch repair system component antikoerper, PMS2 antikoerper

Hintergrund:

Synonyms: PMS1 homolog 2, mismatch repair system component , HNPCC4 , MLH4 , PMS2CL , PMSL2

Background: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq]

Molekulargewicht: 96 kDa

Gen-ID: 5395

UniProt: P54278