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PHAX Antikörper

PHAX Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7469234
  • Target Alle PHAX Antikörper anzeigen
    PHAX (phosphorylated Adaptor For RNA Export (PHAX))
    Reaktivität
    • 36
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Human
    Wirt
    • 36
    Kaninchen
    Klonalität
    • 36
    Polyklonal
    Konjugat
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PHAX Antikörper ist unkonjugiert
    Applikation
    • 26
    • 20
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human PHAX. The exact sequence is proprietary.
    Isotyp
    IgG
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  • Applikationshinweise
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: 293T

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    PHAX (phosphorylated Adaptor For RNA Export (PHAX))
    Andere Bezeichnung
    PHAX (PHAX Produkte)
    Synonyme
    RNUXA antikoerper, 2810055C14Rik antikoerper, 4933427L19Rik antikoerper, AU018701 antikoerper, AU018854 antikoerper, D18Ertd65e antikoerper, Rnuxa antikoerper, p55 antikoerper, phosphorylated adaptor for RNA export antikoerper, PHAX antikoerper, Phax antikoerper
    Hintergrund

    Synonyms: phosphorylated adaptor for RNA export , RNUXA

    Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

    Molekulargewicht
    44 kDa
    Gen-ID
    51808
    UniProt
    Q9H814
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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