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Rekombinanter PROC Antikörper

PROC Reaktivität: Human ELISA, Purif, BP Wirt: Maus Monoclonal HPC-4 unconjugated Recombinant Antibody
Produktnummer ABIN7487753
  • Target Alle PROC Antikörper anzeigen
    PROC (Vitamin K-dependent protein C (PROC))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 88
    • 13
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 64
    • 17
    • 10
    • 3
    • 3
    • 1
    • 1
    Maus
    Klonalität
    • 70
    • 28
    • 1
    Monoklonal
    Konjugat
    • 66
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser PROC Antikörper ist unkonjugiert
    Applikation
    • 60
    • 46
    • 26
    • 15
    • 15
    • 11
    • 11
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Purification (Purif), Blocking Peptide (BP)
    Verwendungszweck
    Anti-Protein C [HPC-4], Mouse IgG1, kappa
    Spezifität
    Specifically binds to a specific twelve peptide sequence (EDQVDPRLIDGK) in the activation region of the Protein C (spanning the thrombin cleavage site). Does not react with activated protein C. Has been shown to be cross-reactive with baboon Protein C but not with bovine or mouse Protein C.
    Kreuzreaktivität
    Pavian
    Produktmerkmale

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    Aufreinigung
    Protein A affinity purified
    Immunogen
    This antibody was raised by immunising mice with human protein C.
    Klon
    HPC-4
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product PROC Primärantikörper
  • Applikationshinweise
    HPC-4 binds human protein C only in the presence of Ca2+, it binds to the reduced carboxymethylated protein C heavy chain, and it blocks protein C activation but does not bind or inactivate protein C or activated protein C bound to its plasma inhibitor. Furthermore, it is an anti-epitope tag antibody, as it recognizes the EDQVDPRLIDGK sequence (Taylor Jr et al., 1987, 3102560). It has been shown to work in ELISAs to determine expression levels (Velander et al., 1992, PMID: 1465430). HPC-4 has been shown to be effective at purifying proteins tagged with its epitope (Rezaie et al., 1992, PMID: 1283093). It has also been used to block the activation of Protein C by the thrombin-thrombomodulin complex (Stearns et al., 1988, PMID: 2447082) and was used for the same purpose in Baboons to lower the threshold of sepsis (Taylor Jr et al., 1987, PMID: 3102560). HPC-4 has been used in many other studies to observe the function of Protein C by knocking out its function in a Ca2+-dependent manner, purification, and others (Tanaka et al., 2006, PMID: 16398653) (Bae et al., 2007, PMID: 17823308).
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    PROC (Vitamin K-dependent protein C (PROC))
    Andere Bezeichnung
    Protein C (PROC Produkte)
    Substanzklasse
    Viral Protein
    Hintergrund
    Autoprothrombin IIA, C-tag, Protein C tag, Protein C-tag, HPC4, Vitamin K-dependent protein C, Anticoagulant protein C, Blood coagulation factor XIV, PROC
    UniProt
    P04070
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