PLEC Antikörper

Produktnummer ABIN7489970

Produktdetails anti-PLEC Antikörper

Target: PLEC (Plectin (PLEC))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PLEC Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human Plectin .

Klon: ARC53240

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:100 – 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Details zu PLEC

Target: PLEC (Plectin (PLEC))

Andere Bezeichnung: Plectin (PLEC Produkte)

Synonyme: EBS1 antikoerper, EBSO antikoerper, HD1 antikoerper, LGMD2Q antikoerper, PCN antikoerper, PLEC1 antikoerper, PLEC1b antikoerper, PLTN antikoerper, AA591047 antikoerper, AU042537 antikoerper, Plec1 antikoerper, Pcn antikoerper, Pltn antikoerper, IFAP300 antikoerper, Plectin-1 antikoerper, plectin antikoerper, plectin L homeolog antikoerper, LOC100481602 antikoerper, plec.L antikoerper, PLEC antikoerper, Plec antikoerper, LOC786966 antikoerper

Hintergrund: Synonyms: HD1; PCN; EBS1; EBSO; PLTN; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17; Plectin
Background: Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .

Gen-ID: 5339

UniProt: Q15149