The mouse monoclonal antibody 9B9 recognizes an extracellular epitope of CD368, a type II transmembrane protein of C lectin family, expressed mainly on monocytes and neutrophils.
Aufreinigung
Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
CLEC4D
Reaktivität: Human
WB
Wirt: Maus
Polyclonal
unconjugated
Applikationshinweise
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
CLEC4D antikoerper, CLEC-6 antikoerper, CLEC6 antikoerper, CLECSF8 antikoerper, MCL antikoerper, MPCL antikoerper, Clecsf8 antikoerper, Mpcl antikoerper, mcl antikoerper, Mcl antikoerper, C-type lectin domain family 4 member D antikoerper, C-type lectin domain family 4, member d antikoerper, C-type lectin domain family 4, member D antikoerper, CLEC4D antikoerper, LOC611536 antikoerper, Clec4d antikoerper
Hintergrund
C-type lectin domain family 4 member D,CD368 is an approximately 25-30 kDa C-type lectin, which serves as one of pattern recognition receptors of the innate immune system. It recognizes pathogen-associated molecular patterns of bacteria and fungi, such as alpha-mannans or trehalose 6,6´-dimycolate, and transfers the signal downstream using associated Fc receptor gamma chain. CD368 is expressed on neutrophils, monocytes, and on some populations of blood dendritic cells, but it decreases during differentiation of monocytes into dendritic cells or macrophages. Increased expression can be induced by IFN-gamma, TNF-alpha, IL-6, and IL-10. CD368 triggering leads to driving of antigen-presenting cells maturation and to promotion of T cell differentiation into Th1 and Th17.,CLEC6, CLEC4D, dectin 3, MCL, MPCL