FCAR Antikörper (APC)

Produktnummer ABIN7505964

Produktdetails anti-FCAR Antikörper (APC)

Target: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCAR Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Verwendungszweck: Anti-Hu CD89 APC

Spezifität: The mouse monoclonal antibody A59 recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages.

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Ag8.653 myeloma cells

Klon: A59

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Details zu FCAR

Target: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Andere Bezeichnung: CD89 (FCAR Produkte)

Synonyme: CD89 antikoerper, Fc fragment of IgA receptor antikoerper, Fc fragment of IgA, receptor for antikoerper, FCAR antikoerper

Hintergrund: Fc fragment of IgA receptor,CD89 (Fc-alpha-R) is a type I transmembrane glycoprotein serving as a receptor for IgA. Soluble CD89 is detectable in serum and retains its IgA binding capacity. For signal transduction the association with FcR gamma chain homodimers is needed. CD89 is expressed on granulocytes, monocytes, macrophages, dendritic cells and myeloid cell lines. Its expression is upregulated in presence of IgA immune complexes, stimulators (such as LPS, PMA), TNF alpha, IL1 beta or GM-CSF, and it is downregulated in presence of TGF beta and suramin. Binding of IgA-opsonized targets to CD89 leads to phagocytic and cytotoxic processes of the immunologic defense.,FcalphaRI, FcAR, CTB-61M7.2

Gen-ID: 2204

UniProt: P24071