TIAL1 Antikörper

Produktnummer ABIN7506023

Produktdetails anti-TIAL1 Antikörper

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Reaktivität: Human, Maus, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIAL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Verwendungszweck: Anti-TIAR Purified

Spezifität: The mouse monoclonal antibody 6E3 recognizes TIAR, an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.

Aufreinigung: Purified by protein-A affinity chromatography.

Immunogen: GST-tagged recombinant human TIAR

Klon: 6E3

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Intracellular staining, recommended dilution: 5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu TIAL1

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Andere Bezeichnung: TIAR (TIAL1 Produkte)

Synonyme: TCBP antikoerper, TIAR antikoerper, 5330433G13Rik antikoerper, AL033329 antikoerper, mTIAR antikoerper, zgc:66130 antikoerper, tcbp antikoerper, tiar antikoerper, TIA1 cytotoxic granule associated RNA binding protein like 1 antikoerper, Tia1 cytotoxic granule-associated RNA binding protein-like 1 antikoerper, TIA1 cytotoxic granule-associated RNA binding protein-like 1 antikoerper, TIAL1 antikoerper, Tial1 antikoerper, tial1 antikoerper

Hintergrund: TIA1 cytotoxic granule associated RNA binding prot,TIAR is an ubiquitously expressed RNA-binding protein, which regulates translational control, splicing, and other activities, including apoptosis. TIAR attenuates CDK1 activity, and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAR shuttles between the cytoplasm and the nucleus, probably as a part of nucleocytoplasmic transport of mRNA, but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAR against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly, e.g. in permeabilized thymocytes TIAR triggers DNA fragmentation.,TCBP, TIAL1

Gen-ID: 7073

UniProt: Q01085