Rekombinanter RSV (Felvizumab Biosimilar) Antikörper
Reaktivität: Respiratory Syncytial Virus (RSV)
ELISA, Func
Wirt: Maus
Chimeric
RSHZ19
unconjugated
Recombinant Antibody
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- Target Alle RSV (Felvizumab Biosimilar) Produkte
- RSV (Felvizumab Biosimilar)
- Antikörpertyp
- Recombinant Antibody
- Reaktivität
- Respiratory Syncytial Virus (RSV)
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Wirt
- Maus
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Klonalität
- Chimeric
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Konjugat
- Dieser RSV (Felvizumab Biosimilar) Antikörper ist unkonjugiert
- Applikation
- ELISA, Functional Studies (Func)
- Verwendungszweck
- Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a, kappa
- Spezifität
- This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.
- Produktmerkmale
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Original Species of Ab: Human
Original Format of Ab: IgG1
- Aufreinigung
- Protein A affinity purified
- Immunogen
- This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
- Klon
- RSHZ19
- Isotyp
- IgG2a kappa
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- Applikationshinweise
- Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
- Kommentare
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- RSV (Felvizumab Biosimilar)
- Abstract
- RSV (Felvizumab Biosimilar) Produkte
- Substanzklasse
- Biosimilar
- Hintergrund
- SB 209763, respiratory syncytial virus
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