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ERK1/2 Antikörper (AA 301-358)

Name: ERK1/2 Antikörper (AA 301-358)
SKU: ABIN723725
Price: 384.62 EUR
Availability: InStock

MAPK1/3 Reaktivität: Human, Maus, Ratte, Schwein WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Mouse placenta lysates probed with ERK1 + ERK2 Polyclonal Antibody, unconjugated at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 60 minutes at 37°C. (ERK1/2 Antikörper (AA 301-358))

Formalin-fixed and paraffin-embedded rat brain labeled with Anti-ERK2/MAPK1 Polyclonal Antibody, Unconjugated (ABIN723725) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, FITC conjugated used at 1:200 dilution for 40 minutes at 37°C. (ERK1/2 Antikörper (AA 301-358))

Formalin-fixed and paraffin embedded rat hippocampus labeled with Anti-ERK2/MAPK1 Polyclonal Antibody, Unconjugated (ABIN723725) at 1:200, followed by conjugation to the secondary antibody and DAB staining (ERK1/2 Antikörper (AA 301-358))

IHC

L1 rat brain, L2 rat heart lysates probed (ABIN723725) at 1:200 in 4 °C. (ERK1/2 Antikörper (AA 301-358))

SDS

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-ERK2/MAPK1 Polyclonal Antibody, Unconjugated (ABIN723725) at 1:200 followed by conjugation to the secondary antibody and DAB staining (ERK1/2 Antikörper (AA 301-358))

IHC

6 Abbildungen

(4 Referenzen)

Produktnummer ABIN723725

Datenblatt (PDF)

Target Alle ERK1/2 (MAPK1/3) Antikörper anzeigen

ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
Bindungsspezifität
51

38

30

30

15

12

12

10

8

7

4

4

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 301-358
Reaktivität
192

160

157

23

22

17

7

3

2

2

2

2

2

1

1

1

1

1
Human, Maus, Ratte, Schwein
Wirt
137

56

4
Kaninchen
Passende Sekundärantikörper
Klonalität
134

63
Polyklonal
Konjugat
91

12

8

5

5

5

5

5

5

5

5

5

5

5

4

4

4

3

3

3

3

3

1

1

1

1
Dieser ERK1/2 Antikörper ist unkonjugiert
Applikation
150

64

50

48

47

38

22

22

20

12

6

4

4

3

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität

Human, Maus, Schwein, Ratte

Homologie

Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from mouse ERK2

Isotyp

IgG
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibody
MAPK1/3 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Zebrafisch (Danio rerio), Hund, Schaf, Fisch, Pferd, Affe WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 300-380) antibody
MAPK1/3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibody
MAPK1/3 Reaktivität: Human, Maus, Ratte, Rind (Kuh) WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr183), (pTyr185) antibody
MAPK1/3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr185), (pThr202) antibody
MAPK1/3 Reaktivität: Human WB, IHC Wirt: Kaninchen Monoclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (C-Term) antibody
MAPK1/3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibody
MAPK1/3 Reaktivität: Human, Maus WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 3F8 unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr183), (pTyr185) antibody
MAPK1/3 Reaktivität: Human, Maus, Ratte, Huhn WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibody
MAPK1/3 Reaktivität: Human WB, DB Wirt: Kaninchen Polyclonal RB15981 unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibody
MAPK1/3 Reaktivität: Human, Maus WB, FACS Wirt: Maus Monoclonal 784CT7-6-3 unconjugated

Applikationshinweise

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit

12 months
Chu, Zhao, Feng, Zhang, Liu, Cheng, Li, Shen, Cao, Li, Min: "MicroRNA-126 participates in lipid metabolism in mammary epithelial cells." in: Molecular and cellular endocrinology, Vol. 454, pp. 77-86, (2017) (PubMed).

Du, Su, Ye, Wang, Huang, Gong: "Pinellia ternata Attenuates Mucus Secretion and Airway Inflammation after Inhaled Corticosteroid Withdrawal in COPD Rats." in: The American journal of Chinese medicine, Vol. 44, Issue 5, pp. 1027-41, (2016) (PubMed).

Sun, Wang, Fu, Chen, Wang, Li, Xing, Li: "Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice." in: BioMed research international, Vol. 2015, pp. 139451, (2015) (PubMed).

Sun, Fu, Liu, Wang, Huo, Guo, Gao, Li, Hu: "Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice." in: Drug design, development and therapy, Vol. 9, pp. 6327-42, (2015) (PubMed).
Target

ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))

Andere Bezeichnung

ERK1 + ERK2 (MAPK1/3 Produkte)

Synonyme

erk1/2 antikoerper, mitogen-activated protein kinase antikoerper, erk1/2 antikoerper

Hintergrund

Synonyms: Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, Mapk1, Erk2, Mapk, Prkm1
Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Gen-ID

26413

UniProt

P63085