Abeta 1-42 Antikörper (AA 1-42)

Produktnummer ABIN725015

Produktdetails anti-Abeta 1-42 Antikörper

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Bindungsspezifität: AA 1-42

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Abeta 1-42 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide of human beta-Amyloid(1-42)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Abeta 1-42 Antikörper (ABIN725015)

Behairi, Belkhelfa, Rafa, Labsi, Deghbar, Bouzid, Mesbah-Amroun, Touil-Boukoffa: "All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats." in: Journal of neuroimmunology, Vol. 300, pp. 21-29, (2017) (PubMed).

Vinothkumar, Kedharnath, Krishnakumar, Sreedhar, Preethikrishnan, Dinesh, Sundaram, Balakrishnan, Shivashekar, Sureshkumar, Venkataraman: "Abnormal amyloid β42expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease." in: BBA clinical, Vol. 8, pp. 20-27, (2017) (PubMed).

Tian, Guo, Wu, Ma, Zhao: "Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats." in: Cellular and molecular neurobiology, (2015) (PubMed).

Wang, Wang: "Studying the relationship between cell cycle and Alzheimer's disease by gold nanoparticle probes." in: Analytical biochemistry, Vol. 489, pp. 32-7, (2015) (PubMed).

Li, Dai, Sun, Xiang, Yang, Dai, Zhang: "Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway." in: Journal of molecular neuroscience : MN, (2015) (PubMed).

Kang, Li, Xing, Li, Su, Fan, Wang, Cui: "Dihydrotestosterone treatment delays the conversion from mild cognitive impairment to Alzheimer's disease in SAMP8 mice." in: Hormones and behavior, Vol. 65, Issue 5, pp. 505-15, (2014) (PubMed).

Zhou, Luo, Dai: "Axonal and Dendritic Changes are Associated with Diabetic Encephalopathy in Rats: An Important Risk Factor for Alzheimer's Disease." in: Journal of Alzheimer's disease : JAD, (2013) (PubMed).

Zhang, Gao, Luo, Chen, Gao, Gao, Zhou, Dai: "Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease." in: PLoS ONE, Vol. 7, Issue 3, pp. e33722, (2012) (PubMed).

Xiao, He, Wang, Luo, Sun, Zhou, Guan, Lucassen, Dai: "The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease." in: Neuroscience bulletin, Vol. 27, Issue 5, pp. 287-99, (2011) (PubMed).

Details zu Abeta 1-42

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Andere Bezeichnung: beta Amyloid 1-42 (Abeta 1-42 Produkte)

Synonyme: amyloid beta precursor protein antikoerper, App antikoerper, APP antikoerper

Hintergrund:

Synonyms: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, Amyloid beta A4 protein, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, A4

Background: The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.

Gen-ID: 351

UniProt: P05067