SOCS1 Antikörper (AA 121-211)
-
- Target Alle SOCS1 Antikörper anzeigen
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
-
Bindungsspezifität
- AA 121-211
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser SOCS1 Antikörper ist unkonjugiert
-
Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Human
- Homologie
- Mouse,Rat,Cow,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Socs 1
- Isotyp
- IgG
- Top Product
- Discover our top product SOCS1 Primärantikörper
-
-
- Applikationshinweise
-
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
- Andere Bezeichnung
- SOCS1 (SOCS1 Produkte)
- Synonyme
- socs1 antikoerper, zgc:91868 antikoerper, jab antikoerper, cis1 antikoerper, ssi1 antikoerper, tip3 antikoerper, cish1 antikoerper, ssi-1 antikoerper, socs-1 antikoerper, SOCS1 antikoerper, LOC100228306 antikoerper, socs1b antikoerper, CIS1 antikoerper, CISH1 antikoerper, JAB antikoerper, SOCS-1 antikoerper, SSI-1 antikoerper, SSI1 antikoerper, TIP3 antikoerper, Cish1 antikoerper, Cish7 antikoerper, Socs-1 antikoerper, suppressor of cytokine signaling 1a antikoerper, suppressor of cytokine signaling 1 antikoerper, suppressor of cytokine signaling 1 L homeolog antikoerper, socs1a antikoerper, socs1 antikoerper, SOCS1 antikoerper, socs1.L antikoerper, Socs1 antikoerper
- Hintergrund
-
Synonyms: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, TIP-3, SOCS1
Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
- Gen-ID
- 8651
- UniProt
- O15524
- Pathways
- JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus
-