Estrogen Receptor alpha Antikörper (AA 331-360)

Produktnummer ABIN725300

Produktdetails anti-Estrogen Receptor alpha Antikörper

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Bindungsspezifität: AA 331-360

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat Estrogen Receptor alpha

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Estrogen Receptor alpha Antikörper (ABIN725300)

Zhou, Li, Wang, Cheng, Ding: "Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17?-estradiol and insulin-like growth factor 1." in: Cell biochemistry and function, Vol. 29, Issue 2, pp. 120-5, (2011) (PubMed).

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: Estrogen Receptor alpha (ESR1 Produkte)

Synonyme: LOC398734 antikoerper, AA420328 antikoerper, AU041214 antikoerper, ER-alpha antikoerper, ER[a] antikoerper, ERa antikoerper, ERalpha antikoerper, ESR antikoerper, Estr antikoerper, Estra antikoerper, Nr3a1 antikoerper, NR3A1 antikoerper, eralpha antikoerper, zfER[a] antikoerper, ER antikoerper, ESRA antikoerper, ESTRR antikoerper, Era antikoerper, akap12 antikoerper, cb27 antikoerper, esr1 antikoerper, fb72g12 antikoerper, id:ibd1202 antikoerper, sb:cb27 antikoerper, si:ch73-192g21.1 antikoerper, wu:fb72g12 antikoerper, wu:fc21c03 antikoerper, Esr antikoerper, RNESTROR antikoerper, ERALPHA antikoerper, er antikoerper, esr antikoerper, nr3a1 antikoerper, XER antikoerper, era antikoerper, esra antikoerper, ERbeta antikoerper, xesr-1 antikoerper, xlERalpha1 antikoerper, xlERalpha2 antikoerper, ESR1 antikoerper, estrogen receptor 1 L homeolog antikoerper, estrogen receptor 1 (alpha) antikoerper, estrogen receptor 1 antikoerper, A kinase (PRKA) anchor protein 12b antikoerper, esr1.L antikoerper, Esr1 antikoerper, ESR1 antikoerper, esr1 antikoerper, akap12b antikoerper

Hintergrund:

Synonyms: Esr, ER-alpha, RNESTROR, Estrogen receptor, ER, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, Esr1, Estr, Nr3a1

Background: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p5 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).

Gen-ID: 24890

UniProt: P06211

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly