Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

HCV Core Protein Antikörper (Biotin)

HCV C Reaktivität: Hepatitis C Virus (HCV) WB Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN726472
  • Target Alle HCV Core Protein (HCV C) Antikörper anzeigen
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Reaktivität
    • 53
    • 4
    • 3
    • 1
    Hepatitis C Virus (HCV)
    Wirt
    • 40
    • 16
    • 4
    Kaninchen
    Klonalität
    • 40
    • 20
    Polyklonal
    Konjugat
    • 35
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HCV Core Protein Antikörper ist konjugiert mit Biotin
    Applikation
    • 40
    • 31
    • 13
    • 12
    • 9
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human, Virus
    Kreuzreaktivität (Details)
    HCV
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from HCV-Core
    Isotyp
    IgG
    Top Product
    Discover our top product HCV C Primärantikörper
  • Applikationshinweise
    WB 1:100-1000
    IHC-P 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Andere Bezeichnung
    HCV Core Protein (HCV C Produkte)
    Substanzklasse
    Viral Protein
    Hintergrund

    Synonyms: Core protein p19, Hepatitis C Virus Core Antigen-C, HCVAg, HCV-Core protein,HCV core antigen, HCV core protein, Hepatitis C Virus core protein, capsid protein, polyprotein precursor, Core protein p21, Core protein p9.

    Background: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage.

    UniProt
    P26664
Sie sind hier:
Kundenservice