Glutathione Reductase Antikörper (AA 421-522)

Produktnummer ABIN728848

Produktdetails anti-Glutathione Reductase Antikörper

Target: Glutathione Reductase (GSR)

Bindungsspezifität: AA 421-522

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutathione Reductase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GSR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Glutathione Reductase Antikörper (ABIN728848)

Khan, Li, Ahmad Khan, Rasul, Nawaz, Sun, Zheng, Ma: "Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction." in: BioMed research international, Vol. 2013, pp. 719858, (2013) (PubMed).

Details zu Glutathione Reductase

Target: Glutathione Reductase (GSR)

Andere Bezeichnung: GLUR/glutathione reductase (GSR Produkte)

Synonyme: GR antikoerper, ATGR2 antikoerper, EMB2360 antikoerper, glutathione reductase antikoerper, AI325518 antikoerper, D8Ertd238e antikoerper, Gr-1 antikoerper, Gr1 antikoerper, DDBDRAFT_0168952 antikoerper, DDBDRAFT_0231410 antikoerper, DDB_0168952 antikoerper, DDB_0231410 antikoerper, 2151 antikoerper, CG2151 antikoerper, DTR antikoerper, Dm-TrxR antikoerper, DmTR antikoerper, DmTrx antikoerper, DmTrxR antikoerper, DmTrxR-1 antikoerper, Dmel\\CG2151 antikoerper, Gr antikoerper, Trx antikoerper, TrxR antikoerper, TrxR-1 antikoerper, Trxr1 antikoerper, anon-WO03040301.185 antikoerper, anon-WO03040301.187 antikoerper, dTrxR antikoerper, dmtrxr-1 antikoerper, gr antikoerper, l(1)G0154 antikoerper, l(1)G0379 antikoerper, l(1)G0477 antikoerper, l(1)G0481 antikoerper, trxr-1 antikoerper, gor1 antikoerper, glutathione reductase, gro-2 antikoerper, glutathione reductase antikoerper, glutathione-disulfide reductase antikoerper, GR; GRase antikoerper, mitochondrial glutathione reductase Pgr1 antikoerper, Glutathione reductase (GR) (GRase) antikoerper, Thioredoxin reductase-1 antikoerper, glutathione-disulfide reductase family protein antikoerper, glutathione reductase 1 antikoerper, GR antikoerper, gor antikoerper, GSR antikoerper, GSR1 antikoerper, Gsr_2 antikoerper, Gsr antikoerper, GSHR1 antikoerper, gsr antikoerper, LbGR antikoerper, pgr1 antikoerper, GSHR2 antikoerper, GLR2 antikoerper, Bcen_2392 antikoerper, RPE_1989 antikoerper, HCAG_02219 antikoerper, SJAG_01162 antikoerper, Trxr-1 antikoerper, PF14_0192 antikoerper, POPTR_0001s14480g antikoerper, gsr1 antikoerper

Hintergrund:

Synonyms: glutathione reductase, GLUR, Glutathione reductase mitochondrial, GR, Gr1, GRase, GRD 1, GRD1, GSR, MGC78522.

Background: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.

Gen-ID: 2890

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis