PDX1 Antikörper (AA 188-284)

Produktnummer ABIN729883

Produktdetails anti-PDX1 Antikörper

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Bindungsspezifität: AA 188-284

Reaktivität: Ratte, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ziege, Ratte

Homologie: Human,Mouse,Pig,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse PDX1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-PDX1 Antikörper (ABIN729883)

Wang, Ren, Hu, Ma, Wang, Liang, Liu: "Effect of Wnt Signaling on the Differentiation of Islet β-Cells from Adipose-Derived Stem Cells." in: BioMed research international, Vol. 2017, pp. 2501578, (2017) (PubMed).

Zheng, Zhai, Li, Ma, Zhu, Du, Li, Hua: "The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation." in: Scientific reports, Vol. 6, pp. 37414, (2016) (PubMed).

Jian, Mao, Xu, Li, Wang, Luo, Zhou, He, Wang, Zhang: "Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells." in: Gene, Vol. 562, Issue 1, pp. 107-16, (2015) (PubMed).

Hefei, Yu, Haiqing, Xiao, Jingyuan, Dongjun: "Morphological Characteristics and Identification of Islet-like Cells Derived From Rat Adipose-derived Stem Cells Cocultured with Pancreas Adult Stem Cells." in: Cell biology international, (2014) (PubMed).

Details zu PDX1

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Andere Bezeichnung: PDX1 (PDX1 Produkte)

Synonyme: GSF antikoerper, IDX-1 antikoerper, IPF1 antikoerper, IUF1 antikoerper, MODY4 antikoerper, PDX-1 antikoerper, STF-1 antikoerper, ipf1 antikoerper, PDX1 antikoerper, IPF-1 antikoerper, Ipf1 antikoerper, Mody4 antikoerper, pdx-1 antikoerper, Idx1 antikoerper, Stf1 antikoerper, zgc:100874 antikoerper, XlHbox-8 antikoerper, xlhbox8 antikoerper, pancreatic and duodenal homeobox 1 antikoerper, pancreatic and duodenal homeobox 1 S homeolog antikoerper, PDX1 antikoerper, pdx1 antikoerper, Pdx1 antikoerper, pdx1.S antikoerper

Hintergrund:

Synonyms: Ipf1, IDX-1, IPF-1, Mody4, STF-1, pdx-1, Pancreas/duodenum homeobox protein 1, Insulin promoter factor 1, Islet/duodenum homeobox 1, Somatostatin-transactivating factor 1, Pdx1

Background: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.

Gen-ID: 18609

UniProt: P52946

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location