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PAK1/2/3 Antikörper (pThr423)

PAK1/2/3 Reaktivität: Human ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN732548
  • Target Alle PAK1/2/3 Antikörper anzeigen
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Bindungsspezifität
    • 11
    • 11
    • 10
    • 10
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr423
    Reaktivität
    • 32
    • 27
    • 26
    • 1
    • 1
    • 1
    Human
    Wirt
    • 33
    Kaninchen
    Klonalität
    • 32
    • 1
    Polyklonal
    Konjugat
    • 26
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PAK1/2/3 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 18
    • 17
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human PAK1 around the phosphorylation site of (Thr423)
    Isotyp
    IgG
    Top Product
    Discover our top product PAK1/2/3 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Andere Bezeichnung
    PAK1/2/3 (PAK1/2/3 Produkte)
    Synonyme
    X-PAK1 antikoerper, XPak1 antikoerper, pak antikoerper, pak-1 antikoerper, pakalpha antikoerper, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antikoerper, p21 (RAC1) activated kinase 1 antikoerper, pak1.S antikoerper, PAK1 antikoerper
    Hintergrund

    Synonyms: PAK1 + PAK2 + PAK3 phospho T423, Alpha PAK, Beta PAK, Gamma PAK, Oligophrenin 3, OPHN3, p21 activated kinase 1, p21 Activated Kinase 1 + 2 + 3, p21 activated kinase 2 , p21 activated kinase 3, P65 PAK, PAK1, PAK2, PAK3, PAK3beta, PAK65, PAKalpha, PAKgamma, S6/H4 kinase, Serine/threonine protein kinase PAK 1, Serine/threonine protein kinase PAK 2, Serine/threonine protein kinase PAK 3, Serine/threonine protein kinase PAK1, Serine/threonine protein kinase PAK2, Serine/threonine protein kinase PAK3, PAK1_HUMAN, PAK2_HUMAN, PAK3_HUMAN.

    Background: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.

    Gen-ID
    5058
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