SOCS2 Antikörper (AA 1-100)

Produktnummer ABIN736028

Produktdetails anti-SOCS2 Antikörper

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Bindungsspezifität: AA 1-100

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Socs 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SOCS2 Antikörper (ABIN736028)

Shin, Riew, Park, Pak, Lee: "Expression of SOCS2 mRNA and protein in the ischemic core and penumbra after transient focal cerebral ischemia in rats." in: Cell and tissue research, Vol. 364, Issue 1, pp. 67-81, (2016) (PubMed).

Letellier, Schmitz, Baig, Beaume, Schwartz, Frasquilho, Antunes, Marcon, Nazarov, Vallar, Even, Haan: "Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer." in: British journal of cancer, Vol. 111, Issue 4, pp. 726-35, (2014) (PubMed).

Zhu, Dai, Han, He, Mo, Chen, Chen, Wu, Yang, Jiang, Chen, Sun, Zhong: "Expression of SOCSs in human prostate cancer and their association in prognosis." in: Molecular and cellular biochemistry, Vol. 381, Issue 1-2, pp. 51-9, (2013) (PubMed).

Details zu SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Andere Bezeichnung: Socs 2 (SOCS2 Produkte)

Synonyme: CIS2 antikoerper, Cish2 antikoerper, SOCS-2 antikoerper, SSI-2 antikoerper, SSI2 antikoerper, STATI2 antikoerper, Cish1 antikoerper, Socs-1 antikoerper, Socs-2 antikoerper, si:dkey-202b22.1 antikoerper, socs2 antikoerper, cis2 antikoerper, ssi2 antikoerper, cish2 antikoerper, ssi-2 antikoerper, socs-2 antikoerper, stati2 antikoerper, 8030460M17 antikoerper, AI527257 antikoerper, AW108012 antikoerper, D130043N08Rik antikoerper, JAB antikoerper, hg antikoerper, Cradd antikoerper, Socs2 antikoerper, suppressor of cytokine signaling 2 antikoerper, suppressor of cytokine signaling 1 antikoerper, death domain-containing protein CRADD antikoerper, suppressor of cytokine signaling 2 S homeolog antikoerper, SOCS2 antikoerper, Socs1 antikoerper, Socs2 antikoerper, socs2 antikoerper, LOC100716104 antikoerper, socs2.S antikoerper

Hintergrund:

Synonyms: CIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2, Suppressor of cytokine signaling 2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SOCS2

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gen-ID: 8835

UniProt: O14508

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus