SPARC Antikörper (AA 101-200)

Produktnummer ABIN738141

Produktdetails anti-SPARC Antikörper

Target: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Bindungsspezifität: AA 101-200

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPARC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SPARC

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SPARC Antikörper (ABIN738141)

Zong, Zeng, Zou, Li, Fang, Lu, Xiao, Zhang: "Effects of Polygonatum sibiricum polysaccharide on the osteogenic differentiation of bone mesenchymal stem cells in mice." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6169-80, (2015) (PubMed).

Kurtul, Eroglu, Unal, Tasdemir, Orhan, Zararsiz, Baran, Kaplan, Kontas: "Prognostic Value of SPARC Expression in Unresectable NSCLC Treated with Concurrent Chemoradiotherapy." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 15, Issue 20, pp. 8911-6, (2014) (PubMed).

Chen, Wang, Xi, Xue, He, Zhang, Zhao: "SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer." in: PLoS ONE, Vol. 7, Issue 8, pp. e42413, (2012) (PubMed).

Details zu SPARC

Target: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Andere Bezeichnung: SPARC (SPARC Produkte)

Synonyme: ON antikoerper, AA517111 antikoerper, BM-40 antikoerper, hm:zeh0062 antikoerper, SPARC antikoerper, sparc antikoerper, secreted protein acidic and cysteine rich antikoerper, secreted acidic cysteine rich glycoprotein antikoerper, secreted protein, acidic, cysteine-rich (osteonectin) antikoerper, secreted protein, acidic, cysteine-rich (osteonectin) L homeolog antikoerper, secreted protein, acidic, cysteine-rich (osteonectin) S homeolog antikoerper, SPARC antikoerper, Sparc antikoerper, sparc antikoerper, sparc.L antikoerper, sparc.S antikoerper

Hintergrund:

Synonyms: ON, SPARC, Basement-membrane protein 4, BM-4, Osteonectin, Secreted protein acidic and rich in cysteine

Background: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites, an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Gen-ID: 6678

UniProt: P09486

Pathways: Autophagie