AGE Antikörper

Produktnummer ABIN738516

Produktdetails anti-AGE Antikörper

Target: AGE (Advanced Glycation End Products (AGE))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Reacts with BSA-AGE.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: AGEs

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-AGE Antikörper (ABIN738516)

Huang, Huang, Xie, Wang, Chen, Shen, Liu, Huang: "Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells." in: Free radical biology & medicine, Vol. 65, pp. 528-40, (2013) (PubMed).

Ye, Yang, Kong, Han, Zhang, Zhang, Li, Liu, Shi, Xiong, Zhao: "Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats." in: Neurochemistry international, Vol. 58, Issue 3, pp. 391-8, (2011) (PubMed).

Lu, Peng, Wang, Wang, Chen, Shen: "Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats." in: Journal of Zhejiang University. Science. B, Vol. 12, Issue 8, pp. 652-9, (2011) (PubMed).

Details zu AGE

Target: AGE (Advanced Glycation End Products (AGE))

Andere Bezeichnung: AGEs (AGE Produkte)

Synonyme: RBP antikoerper, RNBP antikoerper, renin binding protein antikoerper, RENBP antikoerper

Substanzklasse: Chemical

Hintergrund:

Synonyms: Advanced Glycation End products, Serum albumin, BSA, ALB

Background: Advanced Glycation End products (AGEs) are the result of a chain of chemical reactions after an initial glycation reaction. The intermediate products are known, variously, as Amadori, Schiff base and Maillard products, named after the researchers who first described them. (The literature is inconsistent in applying these terms. For example, Maillard reaction products are sometimes considered intermediates and sometimes end products.) Side products generated in intermediate steps may be oxidizing agents (such as hydrogen peroxide), or not (such as beta amyloid proteins). "Glycosylation" is sometimes used for "glycation" in the literature, usually as 'non-enzymatic glycosylation. The AGE-modified BSA was produced by reacting BSA with glycolaldehyde under sterile conditions followed by extensive dialysis and purification steps.

Gen-ID: 280717

UniProt: P02769