SCARB1 Antikörper (AA 21-100)

Produktnummer ABIN738936

Produktdetails anti-SCARB1 Antikörper

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Bindungsspezifität: AA 21-100

Reaktivität: Human, Ratte, Maus, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SCARB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Huhn, Human, Maus, Ratte

Homologie: Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD36L1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SCARB1 Antikörper (ABIN738936)

Gabriel, Becher-Deichsel, Hlavaty, Mair, Walter: "The physiological expression of scavenger receptor SR-B1 in canine endometrial and placental epithelial cells and its potential involvement in pathogenesis of pyometra." in: Theriogenology, Vol. 85, Issue 9, pp. 1599-1609.e2, (2016) (PubMed).

Pollard, Blesso, Zabalawi, Fulp, Gerelus, Zhu, Lyons, Nuradin, Francone, Li, Sahoo, Thomas, Sorci-Thomas et al.: "Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester ..." in: The Journal of biological chemistry, Vol. 290, Issue 25, pp. 15496-511, (2015) (PubMed).

Details zu SCARB1

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Andere Bezeichnung: Scavenger receptor class B member 1 (SCARB1 Produkte)

Hintergrund:

Synonyms: CLA1, SRB1, CLA-1, SR-BI, CD36L1, HDLQTL6, Scavenger receptor class B member 1, CD36 and LIMPII analogous 1, CD36 antigen-like 1, Collagen type I receptor, thrombospondin receptor-like 1, CD36, SCARB1

Background: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

Gen-ID: 949

UniProt: Q8WTV0

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interaktom