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PKM2 Antikörper (pTyr105)

Name: PKM2 Antikörper (pTyr105)
SKU: ABIN744773
Price: 384.62 EUR
Availability: InStock

PKM2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Protein: mouse liver lysates, 30ug; Primary: Anti-Phospho-PKM2(Tyr105) at 1: 5000; ECL excitated the fluorescence; Predicted band size : 58kD Observed band size : 58kD (PKM2 Antikörper (pTyr105))

Formalin-fixed and paraffin embedded human liver carcinoma labeled with Anti-Phospho-PKM2 (Tyr105) Polyclonal Antibody, Unconjugated (ABIN744773) at 1:200 followed by conjugation to the secondary antibody and DAB staining (PKM2 Antikörper (pTyr105))

IHC

Formalin-fixed and paraffin embedded human endometrium tissue labeled with bs-3334R, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (PKM2 Antikörper (pTyr105))

IHC (p)

Formalin-fixed and paraffin embedded rat thyroid labeled with Rabbit Anti-PKM2 (Tyr105) Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (PKM2 Antikörper (pTyr105))

IHC (p)

ELISA

5 Abbildungen

Produktnummer ABIN744773

Datenblatt (PDF)

Target Alle PKM2 Antikörper anzeigen

PKM2 (Pyruvate Kinase M2 (PKM2))
Bindungsspezifität
20

16

16

12

7

7

7

7

7

6

6

6

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr105
Reaktivität
149

104

92

4

4

2

2

2

2

2

1

1

1
Human, Maus, Ratte
Wirt
127

22

5
Kaninchen
Passende Sekundärantikörper
Klonalität
133

21
Polyklonal
Konjugat
57

12

9

9

9

9

9

9

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1
Dieser PKM2 Antikörper ist unkonjugiert
Applikation
85

33

26

26

23

19

14

12

9

7

6

5

2

2

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität

Human, Maus, Ratte

Homologie

Dog,Cow,Pig,Horse,Rabbit,Guinea Pig

Aufreinigung

Purified by Protein A.

Immunogen

KLH conjugated synthetic phosphopeptide derived from human PKM2 around the phosphorylation site of Tyr105

Isotyp

IgG

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anti-Pyruvate Kinase M2 (PKM2) (AA 383-417), (C-Term) antibody
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anti-Pyruvate Kinase M2 (PKM2) (AA 255-350) antibody
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anti-Pyruvate Kinase M2 (PKM2) (AA 121-151), (N-Term) antibody
PKM2 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB5870 unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 116-145), (N-Term) antibody
PKM2 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB15338 unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 1-531) antibody
PKM2 Reaktivität: Human WB, PLA Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit

12 months
Target

PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung

PKM2 (PKM2 Produkte)

Synonyme

CTHBP antikoerper, OIP3 antikoerper, PK3 antikoerper, PKM2 antikoerper, TCB antikoerper, THBP1 antikoerper, AA414905 antikoerper, AL024370 antikoerper, AL024424 antikoerper, Pk-2 antikoerper, Pk-3 antikoerper, Pk3 antikoerper, Pkm2 antikoerper, PKM12 antikoerper, PKM antikoerper, pyruvate kinase M1/2 antikoerper, pyruvate kinase, muscle antikoerper, PKM antikoerper, Pkm antikoerper

Hintergrund

Synonyms: Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58, PKM, OIP3, PK2, PK3, PKM2
Background: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Gen-ID

5315

UniProt

P14618

Pathways

Warburg Effekt