MAP2K4 Antikörper (pSer257, pThr261)

Produktnummer ABIN745673

Produktdetails anti-MAP2K4 Antikörper

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Bindungsspezifität: pSer257, pThr261

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human SEK1/MKK4 around the phosphorylation site of Ser257/Thr261

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Andere Bezeichnung: MEK4 + (MAP2K4 Produkte)

Hintergrund:

Synonyms: MEK4 phospho S257 + T261, SEK1/MKK4Ser257 + Thr261, MAP2K4phospho S257 + T261, MKK4 phospho Ser257 + Thr261, p-MKK4 Ser257 + Thr261, c Jun N terminal kinase kinase 1, c-Jun N-terminal kinase kinase 1, c-Jun N-terminal kinase kinase 1, Dual specicity mitogen activated protein kinase kinase 4, Dual specicity mitogen activated protein kinase kinase 4, Dual specicity mitogen-activated protein kinase kinase 4, JNK activated kinase 1, JNK Activated Kinase 1, JNK activating kinase 1, JNK activating kinase 1, JNK-activating kinase 1, JNKK 1, JNKK, JNKK, JNKK-1, JNKK-1, JNKK1, JNKK1, MAP kinase kinase 4, MAP kinase kinase 4, MAP2K4, MAPK / ERK kinase 4, MAPK / ERK kinase 4, MAPK ERK kinase 4, MAPK/ERK kinase 4, MAPKK 4, MAPKK 4, MAPKK-4, MAPKK-4, MAPKK4, MAPKK4, MEK 4, MEK 4, MEK-4, MEK-4, MEK4, Mitogen Activated Protein Kinase Kinase 4, MKK 4, MKK-4, MKK-4, MKK4, MKK4, MP2K4_HUMAN, PRKMK 4, PRKMK 4, PRKMK-4, PRKMK-4, PRKMK4, PRKMK4, SAPK / ERK kinase 1, SAPK / ERK kinase 1, SAPK ERK kinase 1, SAPK/ERK Kinase 1, SEK 1, SEK1, SEK1, SERK 1, SERK-1, SERK-1, SERK1, SERK1

Background: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gen-ID: 6416

Pathways: MAPK Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling