Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Smad1/5 Antikörper (pSer463, pSer465)

SMAD1/5 Reaktivität: Maus, Ratte IF (cc), IF (p), WB, ELISA, IHC (fro), IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN746033
  • Target Alle Smad1/5 (SMAD1/5) Produkte
    Smad1/5 (SMAD1/5) (Smad1/5 Protein (SMAD1/5))
    Bindungsspezifität
    • 16
    • 14
    • 14
    pSer463, pSer465
    Reaktivität
    • 17
    • 15
    • 15
    Maus, Ratte
    Wirt
    • 31
    Kaninchen
    Klonalität
    • 31
    Polyklonal
    Konjugat
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser Smad1/5 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 25
    • 15
    • 14
    • 5
    • 5
    • 5
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Spezifität
    This phosphorylation site is homologous in the listed cross reactive species at the specified location.
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human Smad1/5 around the phosphorylation site of Ser463/465
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Smad1/5 (SMAD1/5) (Smad1/5 Protein (SMAD1/5))
    Andere Bezeichnung
    Smad1/5 + (SMAD1/5 Produkte)
    Hintergrund

    Synonyms: Smad1 phospho S463/465, Smad1 phospho Ser463/465, p-Smad1 Ser463/465, Mothers against decapentaplegic homolog 1, BSP 1, BSP1, BSP-1, Dwarfin A, DwfA, hSMAD 1, hSMAD1, JV 41, JV4 1, JV4-1, JV41, MAD mothers against decapentaplegic homolog 1, Mad related protein 1, MADH 1, MADH1, Madr 1, MADR1, Mothers against decapentaplegic homolog 1, Mothers against DPP homolog 1, Sma and Mad related protein 1, SMAD 1, SMAD-1, SMAD family member 1, SMAD mothers against DPP homolog 1 Drosophila, Spinal muscular atrophy distal with upper limb predominance, TGF beta signaling protein 1, Transforming growth factor beta signaling protein 1, SMAD1_HUMAN, MAD homolog 1, Mothers against DPP homolog 1, Mad-related protein 1, SMAD family member 1, Smad1, Transforming growth factor-beta-signaling protein 1.

    Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].

    Gen-ID
    4086, 4090
Sie sind hier:
Kundenservice