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MST1 Antikörper (AA 385-487) (Cy3)

MST1 Reaktivität: Human, Maus, Ratte WB, FACS, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN747311
  • Target Alle MST1 Antikörper anzeigen
    MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))
    Bindungsspezifität
    • 15
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 385-487
    Reaktivität
    • 82
    • 39
    • 33
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 77
    • 8
    Kaninchen
    Klonalität
    • 79
    • 6
    Polyklonal
    Konjugat
    • 29
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MST1 Antikörper ist konjugiert mit Cy3
    Applikation
    • 49
    • 27
    • 25
    • 23
    • 12
    • 12
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MST1
    Isotyp
    IgG
    Top Product
    Discover our top product MST1 Primärantikörper
  • Applikationshinweise
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))
    Andere Bezeichnung
    MST1 (MST1 Produkte)
    Synonyme
    D3F15S2 antikoerper, DNF15S2 antikoerper, HGFL antikoerper, MSP antikoerper, NF15S2 antikoerper, E2F2 antikoerper, D3F15S2h antikoerper, D9H3F15S2 antikoerper, DNF15S2h antikoerper, Hgfl antikoerper, HGF1/MSP antikoerper, E1A antikoerper, XHL antikoerper, d3f15s2 antikoerper, dnf15s2 antikoerper, hgfl antikoerper, msp antikoerper, mst1 antikoerper, nf15s2 antikoerper, macrophage stimulating 1 antikoerper, macrophage stimulating 1 (hepatocyte growth factor-like) antikoerper, serine/threonine kinase 4 antikoerper, macrophage stimulating 1 L homeolog antikoerper, MST1 antikoerper, Mst1 antikoerper, STK4 antikoerper, mst1.L antikoerper
    Hintergrund

    Synonyms: KRS2, MST1, YSK3, TIIAC, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2, STK4

    Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

    Gen-ID
    6789
    UniProt
    Q13043
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