Id2 Antikörper (AA 31-134)

Produktnummer ABIN747473

Produktdetails anti-Id2 Antikörper

Target: Id2 (Inhibitor of DNA Binding 2 (Id2))

Bindungsspezifität: AA 31-134

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Id2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Due to the similarity of this protein with ID1, this antibody has a chance to have light cross-reactivity with ID1 due to a 77 % sequence similarity in the range of our immunogen.

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GIG8/ID2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Id2

Target: Id2 (Inhibitor of DNA Binding 2 (Id2))

Andere Bezeichnung: ID2 (Id2 Produkte)

Synonyme: AI255428 antikoerper, C78922 antikoerper, Idb2 antikoerper, bHLHb26 antikoerper, Ac2-300 antikoerper, GIG8 antikoerper, ID2A antikoerper, ID2H antikoerper, XId2 antikoerper, id2-A antikoerper, inhibitor of DNA binding 2 antikoerper, inhibitor of DNA binding 2, HLH protein antikoerper, inhibitor of DNA binding 2 L homeolog antikoerper, Id2 antikoerper, ID2 antikoerper, id2.L antikoerper

Hintergrund:

Synonyms: GIG8, ID2A, ID2H, bHLHb26, DNA-binding protein inhibitor ID-2, Class B basic helix-loop-helix protein 26, Inhibitor of DNA binding 2, Inhibitor of differentiation 2, ID2

Background: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gen-ID: 3398

UniProt: Q02363